Tyrosine-protein kinase transmembrane receptor ROR2

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Investigator: Natalia Z. Jura, PhD
Sponsor: SAIC-Frederick

Location(s): United States

Description

In the Jura lab we are interested in understanding the molecular basis for spatial and temporal integration of signaling at the plasma membrane, by focusing on one group of the membrane receptors - Receptor Tyrosine Kinases. We are developing tools for the in vitro mechanistic studies and structural investigation of these receptors and their feedback regulators in the membrane environment. We are also establishing single cell assays to quantitatively measure the signaling responses elicited by these receptors in vivo. The underlying motivation for these efforts is to identify small molecule modifiers of receptor function that could be used to adjust their abnormal signaling in human diseases.