ProTECT III is a research study designed to see if progesterone, a hormone naturally produced in the body, can reduce the amount of brain damage caused by a traumatic brain injury. Previous studies suggest that progesterone, given immediately after a TBI, may help treat brain injuries by reducing brain swelling and damage.

There is no specific drug treatment for the treatment of traumatic brain injury. The reason for doing this study is to find out if progesterone is a safe, successful pharmaceutical way to treat TBI, and the brain damage that TBI causes. If the trial is successful, and progesterone does help brain injury patients get better, it will mean a big improvement in TBI treatment!