Samples from Brazilian Aging Brain Study Group

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Investigator: Lea T. Grinberg, MD, PhD

Location(s): Brazil

Description

Alzheimer’s disease (AD) is the most common cause of dementia in the human population, characterized by a spectrum of neuropathological abnormalities that results in memory impairment and loss of other cognitive processes as well as the presence of non-cognitive symptoms. Transcriptomic analyses provide an important approach to elucidating the pathogenesis of complex diseases like AD, helping to figure out both pre-clinical markers to identify susceptible patients and the early pathogenic mechanisms to serve as therapeutic targets. This study provides the gene expression profile of postmortem brain tissue from subjects with clinic-pathological AD. No study to date have addressed whether specific patterns of gene expression is associated to the development of AD-related pathology and to the clinical manifestation of dementia in subjects with significant AD pathology. Therefore, the aims of this study were: (1) to determine which genes and their biological functions are related to the development of AD pathology; (2) to determine which genes and their biological functions are related to the clinical manifestation of dementia in subjects with significant AD pathology. Hippocampal specimens were obtained from the Brain Bank of the Brazilian Aging Brain Study Group.