A Randomized Phase IIB Open Label Study of Nivolumab or Nivolumab in Combination with Ipilimumab Versus Bevacizumab in Adult Subjects with Recurrent Glioblastoma (GBM)

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Investigator: Nicholas Butowski, MD
Sponsor: Bristol-Myers Squibb Company

Location(s): United States

Description

The purposes of the study are to understand the

  1. Safety and tolerability of Nivolumab and Nivolumab in combination with Ipilimumab in a safety lead-in phase (Cohort 1, 1b) and
  2. The safety, tolerability and efficacy of Nivolumab versus Bevacizumab (Cohort 2) in patients diagnosed with recurrent glioblastoma (GBM).