A Randomized Controlled Trial of Vitamin D Supplementation in Multiple Sclerosis

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Investigator: Emmanuelle L. Waubant, MD, PhD
Sponsor: Johns Hopkins University

Location(s): United States

Description

Assess the effectiveness of vitamin D supplementation in patients with multiple sclerosis (MS).  This trial is being done because previous studies of vitamin D levels in people with MS show that those with lower vitamin D levels are more likely to have MS attacks and new MS lesions develop on brain MRI, but it is not known if giving vitamin D supplements reduces the amount of MS activity. 

This is a multicenter trial in which participants with relapsing-remitting MS will be receive high-dose or low-dose vitamin D for two years.  All participants will be given glatiramer acetate (Copaxone) for free during the study.  The purpose of the study is to assess if vitamin D is effective in reducing relapses and new MRI lesions in people with multiple sclerosis.