Building on the pathogen surveillance, viral discovery, and global health capacity strengthening efforts conducted in more than 20 countries during EPT 1, PREDICT 2 is continuing efforts to shift the prevention and surveillance paradigm towards identification and mitigation of viral spillover and amplification risk by: identifying and better characterizing pathogens of known epidemic and unknown pandemic potential; recognizing animal reservoirs and amplification hosts of human-infectious viruses; and efficiently targeting intervention action at human behaviors which amplify disease transmission at critical animal-animal and animal-human interfaces in hotspots of viral evolution, spillover, amplifica-tion, and spread. To achieve these objectives, PREDICT 2 is working with EPT and other partners to operationalize effective One Health platforms that increase knowledge and strengthen functional technological capacities in local, national, and regional contexts for surveillance system design, field sampling, laboratory techniques, behavioral risk characterization, information management, public data dissemi-nation, and data analytics and forecasting.

PREDICT 2 is focusing efforts on the highest risk locations and interfaces, where animals and people share changing landscapes, and diseases of unknown origin continue to take a significant toll. Using an epizonal approach, PREDICT is targeting surveillance activities at three major pandemic risk pathways that drive viral emergence: land conversion for commercialization, intensification of animal production systems, and animal value chains.