PAAR4Kids-Pharmacogenomics Research Network

-
Investigator: Mignon Loh, MD
Sponsor: St. Jude Children's Research Hospital

Location(s): United States

Description

The goal of PAAR4Kids is to fully define the pharmacogenomics of childhood acute lymphoblastic leukemia (ALL), the most common childhood malignancy, in order to improve the lives of children with this disease, as well as any patients treated with the same medications.

Our aims are to define genomic variations (germline and acquired) important for interpatient variability in treatment response and toxicity from medications used to treat childhood ALL, to translate pharmacogenomics into clinical treatment strategies, and to collaborate with pharmacogenomics investigators to leverage relevant pharmacogenomic knowledge from pediatric ALL to other diseases and disciplines (and vice-versa). This is accomplished by a multidisciplinary team of leaders in the field.