Nonlinear Mixed Effects Modeling of Rifapentine in Children

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Investigator: Rada Savic, PhD
Sponsor: National Foundation for the CDC and Prevention

Location(s): Kenya; South Africa; China; Viet Nam; Peru; United States

Description

We will perform nonlinear mixed effects (NLME) modeling of TBTC Study data to evaluate:

– Autoinduction and its relationship to dose

– Drug/metabolite relationships

– Absorptionandclearance kinetics/saturability and relationship to dose