Manipulation of Macrophage Responses by M. tuberculosis
Location(s): United States
How the TB bacillus interacts with host cells in order to grow during infection is not well understood. The primary objective of the proposed research is to understand the mechanisms by which this pathogen triggers and manipulates host responses of macrophages. Understanding how macrophages sense M. tuberculosis infection and begin to initiate the cytosolic surveillance pathway specific to virulent M. tuberculosis may help in the development of new TB treatments and diagnostics, as well as diagnostics for a broad range of infectious diseases. Ultimately, by understanding tuberculosis pathogenesis at the molecular level, we hope to aid in the discovery of new therapies to combat and eradicate the pathogen.