Investigating the Neurodegenerative Mechanisms Underlying Glaucoma

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Investigator: Yvonne Ou, MD
Sponsor: Research to Prevent Blindness, Inc.

Location(s): United States

Description

Glaucoma is a neurodegenerative disorder characterized by retinal ganglion cell (RGC) loss with optic nerve cupping and visual field defects. Disease mechanisms are not well understood, but evidence suggests that the pathological degeneration of a stressed RGC is compartmentalized at the subcellular level, with changes in the synaptic, dendritic, and axonal compartments. The purpose of this study is to determine the effects of laser-induced ocular hypertension (LIOH) on excitatory synapse number in the inner plexiform layer of the retina.