We are continuing our systematic screening of the autosomal genome for strong evidence of a genetic linkage between a major locus for Gilles de la Tourette Syndrome (GTS) and the simple Mendelian polymorphic markers that we are typing. This work will involve both typing of additional markers and re-analysis of all existing marker data using revised/updated diagnoses and genetic models. We will continue to concentrate our typing efforts on the Oregon kindred (52 individuals being typed) and on branch C (66 individuals) of the larger Canadian kindred in order to cover the genome more rapidly with markers.