The Genetic Epidemiology of RA and SLE

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Investigator: Lindsey A. Criswell, MD, MPH
Sponsor: NIH Natl Inst Arthr, Musculoskel & Skin

Location(s): United States

Description

During the past six years, Dr. Criswell's research program has focused on the genetic epidemiology of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This work has led to several important findings, including the association of tumor necrosis factor polymorphism with RA severity through an interaction with the HLA-DRB 1 shared epitope. Due to the rapid pace of advances in analytic methods for genetically complex diseases such as RA and SLE, Dr. Criswell must continue to devote a substantial amount of time and effort to mastering these rapidly evolving methods. This application describes 3 projects that utilize state of the art methods to identify genetic and non-genetic risk factors for these complex diseases. The expertise of the study investigators in the areas of rheumatology, genetics and statistics, in conjunction with the progress of these studies to date, ensures a high likelihood of success for this work. The research environment at UCSF provides an outstanding environment in which Dr. Criswell can continue to develop as a leader in patient-oriented clinical research and as a mentor to junior clinical investigators. As a result of Dr. Criswell's role as the Associate Director of the UCSF General Clinical Research Center (GCRC), she is ideally positioned to make a major impact at UCSF as a mentor for young clinical investigators.