Genetic Determinants of Capecitabine Toxicity

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Investigator: Hope Rugo, MD
Sponsor: Johns Hopkins University

Location(s): United States

Description

The purpose of this study is to identify possible genetic polymorphisms that contribute to specific toxicities associated with capecitabine (hand-foot syndrome, diarrhea, and neutropenia).

Additionally, this study will look at gene polymorphisms in patients experiencing the toxicities of interest, the frequency of polymorphisms and differences in drug metabolism.