My research focus is on the definition of pathogenic mechanisms of viral diseases, particularly HIV disease. This focus has spanned a range of fields, from understanding critical structural determinants of infectivity , to devising a small animal model, to study HIV pathogenesis and to prioritize antiretroviral compounds against HIV, to studying mechanisms of T cell depletion and repletion in vivo. Throughout this body of work, hypothesis-driven, patient-oriented research has been pursued with collaborative teams of basic scientists, translational researchers, and clinicians. Ever more attention has been devoted to understanding the correlates of protective immunity against HIV, with the specific intent to work with others to develop an effective vaccine. This is the purpose of the Division of Experimental Medicine, in which multiple investigators working on the human immunology of chronic infectious diseases (e.g., HIV, TB, malaria, etc) work together. Faculty in the Division have collaborations that span the globe.