Determination of the Biological Variability (BV) of the Hevylite (HL) Assays.

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Investigator: Alan H. Wu, PhD
Sponsor: Binding Site, Inc.

Location(s): United States

Description

Immunoglobulin molecules contain unique junctional epitopes between the heavy chain (CH1) and light chain (CL) constant regions. These are the target of HLC antibodies, which can identify  different light chain types.  (IgGκ, IgGλ, IgAκ, IgAλ, IgMκ and IgMλ) These molecules are then measured in pairs, e.g., IgGκ/IgGλ, to produce ratios of involved immunoglobulin/background polyclonal immunoglobulin concentrations,.