Cumulative Risk for Preterm Birth by Characteristics and Biomarkers Across Pregnancies in African-American Women

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Investigator: Laura L. Jelliffe, PhD, MS
Sponsor: UCSF Preterm Birth Initiative (PTBi)

Location(s): United States

Description

Using 35 metabolic markers analyzed by mass spectrometry from newborn heel stick blood samples, this team was able to identify term and preterm newborns with more than 95% accuracy in a cohort of 700,000 California babies. They were able to assign a week of gestation within two weeks in approximately 90% of newborns.

With co-funding from BMGF Grand Challenges and UCSF PTBi-EA, validation work is being conducted in Tororo to test the algorithm on more than 800 newborns, as well as existing banked biospecimens.