Center for RNA Systems Biology

Investigator: Jonathan S. Weissman, PhD
Sponsor: University of California Berkeley

Location(s): United States


Established in 2012 and supported by the National Institutes of Health, the Center for RNA Systems Biology (CRSB) will use systems biology to establish a fundamental basis for understanding and predicting the control of mRNA fate due to RNA structure embedded in pre-mRNA and mRNA sequences. Employing a suite of tools, researchers will detect pre-mRNA and mRNA structural features in human cells at a systems level.

The ultimate goal of the CRSB is to map the relationship between the placement of RNA structure in a pre-mRNA or mRNA sequence and mRNA fate. Rather than focusing on specific examples, Center researchers will obtain global data on RNA structure, from which underlying principles for all human pre-mRNAs and mRNAs may be obtained.