The Amyotrophic Lateral Sclerosis (ALS)/Parkinsonism-Dementia Complex of Guam: Exploring the Mechanism of a Rare Tauopathy

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Investigator: Michael D. Geschwind, MD, PhD
Sponsor: CurePSP

Location(s): Northern Mariana Islands; Guam

Description

A unique clinical syndrome of amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) is seen in Guam but other neurodegenerative diseases are also present. Much of the focus has been on the cognitive aspects of these dementias, while it is now known that neuropsychiatric symptoms feature prominently in neurodegenerative disease.