Advanced Methods to Evaluate Extracellular Matrix and Crosslinking in the Tumor Microenvironment

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Investigator: Valerie M. Weaver, PhD
Sponsor: University of Colorado Denver, Anschutz Medical Campus

Location(s): United States

Description

To build upon a successful IMAT R21-supported project to improve proteomic analysis of the ECM (by using) a variety of approaches, including pulsed 13C-labeling of proteins, MRM-MS and (isostable) affinity tagging (for ability) will be used to investigate the composition of the ECM in relation to tumor development and metastasis. They will validate the approach on established murine models for breast and pancreatic cancer.