Department of Neurological Surgery

Active Projects: 14

Project Investigator All Organizations Start date
End date
Understanding the Role of Altered Metabolism in Gliomagenesis Russell Pieper, PhD Department of Neurological Surgery
PNOC-002: Safety, Phase 0, and Pilot Efficacy Study of vemurafenib, an oral inhibitor of BRAFV600E, in Children with Recurrent/Refractory BRAFV600E-mutant gliomas Michael D. Prados, MD Department of Neurological Surgery
DLM-10-001: An Open-Label, Single Arm, Safety and Tolerability Dose-escalation Study of DAG in Patients with Recurrent Malignant Glioma or Progressive Secondary Brain Tumor Nicholas Butowski, MD Department of Neurological Surgery
Brain Tumor Spore Grant Mitchel S. Berger, MD Department of Neurological Surgery
Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK TBI) Geoffrey Manley, MD, PhD Department of Neurological Surgery
Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Geoffrey Manley, MD, PhD Department of Neurological Surgery
BGJ398X2201 - A Phase 2, multicenter, open-label study of BGJ398 in patients with recurrent resectable or unresectable Glioblastoma Nicholas Butowski, MD Department of Neurological Surgery
A Randomized Phase IIB Open Label Study of Nivolumab or Nivolumab in Combination with Ipilimumab Versus Bevacizumab in Adult Subjects with Recurrent Glioblastoma (GBM) Nicholas Butowski, MD Department of Neurological Surgery
BRAF Mutation in Malignant Astrocytoma Origin, Evolution, and Response to Therapy Claudia Petritsch, PhD Department of Neurological Surgery
Track TBI Biorepository Subcontract Geoffrey Manley, MD, PhD Department of Neurological Surgery
A Phase 1/2 Study of SL-701, a Subcutaneously Injected Multivalent Glioma-Associated Antigen Vaccine, in Adult Patients with Recurrent Glioblastoma Multiforme Nicholas Butowski, MD Department of Neurological Surgery
A Phase 1 Study Evaluating the Safety and Pharmacokinetics of ABT-414 for Subjects with Glioblastoma Multiforme Nicholas Butowski, MD Department of Neurological Surgery
Training Program in Translational Brain Tumor Research Joseph Costello, PhD Department of Neurological Surgery, Helen Diller Family Comprehensive Cancer Center
Phase II Study of MK-3475 with and without Bevacizumab for Recurrent Glioblastoma Jennifer L. Clarke, MD, MPH Department of Neurological Surgery

Archived Projects: 21

Project Investigator All Organizations Start date
End date
Adjuvant Treatment with Temodar plus Avastin Alone or with Tarceva in Patient with Newly Diagnosed Glioblastoma Multiforme Who Are Stable Following Radiotherapy with Temodar Michael D. Prados, MD Department of Neurological Surgery
Phase II Study of 7 Days On/7 Days Off Temozolomide in Patients with High Grade Glioma Nicholas Butowski, MD Department of Neurological Surgery
Adult Brain Tumor Consortium (ABTC) Michael D. Prados, MD Department of Neurological Surgery
ProTECT III: Progesterone for the Treatment of Traumatic Brain Injury Geoffrey Manley, MD, PhD Department of Neurological Surgery
A PTEN-Regulated Ubiquitin Switch Controlling TRAIL Sensitivity in GBM Russell Pieper, PhD Department of Neurological Surgery
Transforming Traumatic Brain Injury Research and Clinical Care Geoffrey Manley, MD, PhD Department of Neurological Surgery
Pivotal IDE Study to Evaluate Ultrasound as Adjunctive Therapy for Increasing Posterolateral Fusion Success Following Single Level Posterior Instrumented Lumbar Surgery Praveen Mummaneni, MD Department of Neurological Surgery
Training Program in Translational Brain Tumor Research Russell Pieper, PhD Department of Neurological Surgery
Spinal Cord Injury With Brain Injury: Bedside To Bench Modeling For Developing Treatment And Rehabilitation Strategies Geoffrey Manley, MD, PhD Department of Neurological Surgery
Genetic and Molecular Epidemiology of Adult Glioma Margaret R. Wrensch, PhD Department of Neurological Surgery
International Case-Control Study of Malignant Glioma Margaret R. Wrensch, PhD Department of Neurological Surgery
A Causal Role for Asymmetric Cell Division Defects in Glioma Initiation Claudia Petritsch, PhD Department of Neurological Surgery
JBAL: A Phase 2 Study of LY2157299 Monohydrate Monotherapy or LY2157299 Monohydrate plus Lomustine Therapy compared to Lomustine Monotherapy in Patients with Recurrent Glioblastoma Nicholas Butowski, MD Department of Neurological Surgery
Radially Branched Delivery Device - MRI Interventions - URC 20121214 Daniel A. Lim, MD, PhD Department of Neurological Surgery
TCGA (Cancer Genome Atlas) Michael D. Prados, MD Department of Neurological Surgery
Task Order # ST01: 10 Prospective Cases of Lower Grade Gliomas (Grades II and Grade III) Michael D. Prados, MD Department of Neurological Surgery
Functional Neural Relay Formation by Human Neural Stem Cell Grafting in Spinal Cord Injury Department of Neurological Surgery
A Phase I Study of Convection-Enhanced, Image-Assisted Delivery of Liposomal-Irinotecan Using Imaging in High Grade Glioma Nicholas Butowski, MD Department of Neurological Surgery
32nd Annual National Neurotrauma Symposium Department of Neurological Surgery
TBI Endpoints Development (TED) Geoffrey Manley, MD, PhD Department of Neurological Surgery
Evaluation of Pao Pereira, a natural product of the extract of rainforest tree, in malignant brain tumor cell lines Nicholas Butowski, MD Department of Neurological Surgery